Image-guided restricted drug release in friendly implanted therapeutics (Vol. 49 No.5-6)

This review exposes a possible therapeutics scheme of using active implants for restricted drug release, accounting for friendly wellbeing and security of patient. Friendly therapeutics ought to use controlled drug release with minimally-invasive and non-ionizing techniques. The review of different issues elucidates that the strategy sought may use non-ionizing image-guided drug release embedded implant, which is powered and controlled wirelessly by an external source. The analysis of the principal biomedical imagers indicates the MR (magnetic resonance) imager as the most adequate non-ionizing solution.

The review of MRI (magnetic resonance imaging) technology suggests an optimization of performance versus biological effects, as well as of compatibility with hosting materials in its environment. For the sake of such compatibility, an EMC (electromagnetic compatibility) analysis has been performed considering the nature of different MRI fields and their conventional protections and corrections.

A possible future strategy would consist of an interactive system operating autonomously. Such a system is composed of the imager, the implant and its external wireless powering/control device. It integrates an AI (artificial intelligence) algorithm and has to operate under the supervision of the health-care team.

A. Razek, Towards an image-guided restricted drug release in friendly implanted therapeutics, Eur. Phys. J. Appl. Phys. 82, 31401 (2018)
[Abstract]