Better chemo drug adsorption onto targeted delivery capsules (Vol. 49 No.5-6)

Adsorption of chemo drug onto active carbon with aluminium inclusion

New study demonstrates adsorption of chemotherapy drugs onto active carbon delivery capsule can be enhanced with aluminium atom inclusions

The efficacy of chemotherapy treatment depends on how effectively it reaches cancerous cells. Increasing targeted delivery could mean decreasing side effects. Scientists are enhancing methods of selectively transmitting active chemotherapy agents and reducing their toxicity by encapsulating chemo drugs into active carbon used as the targeted delivery device. In a new study published recently, the authors have demonstrated that adding minute amounts of aluminium atoms onto activated carbon atoms helps increase the adsorption onto the delivery carbon capsule of a standard chemotherapy drug, called 5-Fluorouracil (5-FU). This drug is typically used for stomach, colorectal, neck and head cancer treatments. This model could lead to more effective and convenient cancer treatments with fewer side effects by encapsulating the chemo drug into the active carbon, so that it can be taken orally.

G. Román, E. Noseda Grau, A. Diaz Compañy, G. Brizuela, A. Juan, and S. Simonetti, A first-principles study of pristine and Al-doped activated carbon interacting with 5-Fluorouracil anticancer drug, Eur. Phys. J. E 41, 107 (2018)